Data Material

Here, the efficacy and safety of ragweed SLIT tablets during peak and throughout the pollen season was evaluated in children and adolescents in a double-blind, placebo-controlled clinical trial (N=1025; 77.8% polysensitized). The mean total combined score (TCS; sum of Daily Rhinoconjunctivitis Symptom Score [DSS] and Daily Medication Score [DMS]) was assessed for the peak (primary endpoint) and the entire ragweed pollen season (key secondary endpoint). DSS and DMS during peak season were other key secondary endpoints. The relative improvement in TCS with ragweed SLIT tablets compared to placebo during the peak season (≈186 grains/m3/day) was -38.3% and during the entire season (≈85 grains/m3/day) was -32.4%. There were no reported events of anaphylaxis, airway compromise, or serious systemic allergic reactions related to treatment. The authors concluded that ragweed SLIT tablets were effective in children with RA/C during peak season, when symptoms were greatest, and throughout the season. To learn more about this study, watch Dr. Anne Ellis' Investigator Insights video here.